Prolyl hydroxylases positively regulated LPS ‐induced inflammation in human gingival fibroblasts via TLR4/MyD88‐mediated AKT/NF‐κB and MAPK pathways

ConclusionsProlyl hydroxylases acted as a positive regulator in LPS ‐induced inflammation of HGFs via TLR4/MyD88‐mediated NF‐κB, MAPK and AKT signalling pathways and PHD2 among three isoforms was principally responsible for the effects.

Source: Cell Proliferation - November 14, 2018 Category: Cytology Authors: Lingling Shang, Ting Wang, Dongdong Tong, Wenyan Kang, Qianyu Liang, Shaohua Ge Tags: ORIGINAL ARTICLE Source Type: research