Class 1 integrons in Acinetobacter baumannii: a weak expression of gene cassettes to counterbalance the lack of LexA-driven integrase repression

The genus Acinetobacter, and principally Acinetobacter baumannii-calcoaceticus complex, has emerged over the past two decades as a cause of both nosocomial and community-acquired infections. The WHO lists A. baumannii among critical antibiotic-resistant "priority pathogens" (http://www.who.int/mediacentre/news/releases/2017/bacteria-antibiotics-needed/en/). Treatment of Acinetobacter infections is increasingly difficult, as these bacteria are intrinsically resistant to multiple antimicrobial agents and have a remarkable ability to adapt rapidly to environmental selection pressure, acquiring new resistance determinants through multiple mechanisms [1].
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Source Type: research