Cefazolin versus anti-staphylococcal penicillins for the treatment of methicillin-susceptible Staphylococcus aureus bloodstream infections in acutely-ill adult patients: results of a systematic review and meta-analysis

Staphylococcus aureus (SA) bloodstream infections (BSI) continue to be a leading cause of morbidity and mortality within healthcare-systems and the intensive-care unit (ICU), in particular [1-3]. The extensive use of intravascular catheters in critically ill patients is a major risk factor in the acquisition of ICU-BSI, with SA representing one of the most commonly isolated organisms in ICU-BSI [3-7]. Prompt initiation of effective antimicrobial therapy is essential to reduce the risk of mortality in BSI, especially in the presence of sepsis and septic shock [8-10].

Source: International Journal of Antimicrobial Agents - November 23, 2018 Category: Drugs & Pharmacology Authors: Benjamin J. Lee, Sheila K. Wang, Janie K. Constantino-Corpuz, Kristel Apolinario, Barbara Nadler, Jennifer S. McDanel, Marc H. Scheetz, Nathaniel J. Rhodes Source Type: research