Recent advances in electrogenerated chemiluminescence biosensing methods for pharmaceuticals

Publication date: Available online 22 November 2018Source: Journal of Pharmaceutical AnalysisAuthor(s): Yu Zhang, Rui Zhang, Xiaolin Yang, Honglan Qi, Chengxiao ZhangAbstractElectrogenerated chemiluminescence (electrochemiluminescence, ECL) generates species at electrode surfaces, which undergoes electron-transfer reactions and forms excited states to emit light. It has become to a very powerful analytical technique and been widely used in such as clinic testing, biowarfare agent detection, and pharmaceutical analysis. This review focuses on the current trends of molecular recognition-based biosensing methods for pharmaceutical analysis since 2010. It introduces a background of ECL and presents the recent ECL developments in ECL immunoassay (ECLIA), immunosensors, enzyme-based biosensors, aptamer-based biosensors, and molecularly imprinted polymers (MIP)-based sensors. At last, the future perspective for these analytical methods is briefly discussed.
Source: Journal of Pharmaceutical Analysis - Category: Drugs & Pharmacology Source Type: research