The application of nitric oxide delivery in nanoparticle-based tumor targeting drug delivery and treatment

Publication date: Available online 22 November 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Lin Qin, Huile GaoAbstractNitric oxide (NO) shows great role in tumor biology. Recent years, more and more researches utilized NO donor in tumor targeting drug delivery and treatment. In this review, we summarized the NO donors by their endogenous and exogenous stimuli. Then the application of NO donors, which was the main aim of the review, was discussed in detailed according to their functions, including inducing tumor cell apoptosis, reversing tumor multidrug resistance, inhibiting tumor metastasis and improving drug delivery.Graphcial abstract In the review, authors summarized the nitric oxide donors, and paid main attention on the functions of NO donors in drug delivery.
Source: Asian Journal of Pharmaceutical Sciences - Category: Drugs & Pharmacology Source Type: research