Role of genomic changes in chromosome 17 and p53 gene in oral squamous cell carcinoma patients by Flouroscence in situ hybridization in Indian population

This study was performed retrospectively on 30 cases diagnosed with OSCC through FISH technique. Molecular cytogenetic techniques, using fluorescence in situ hybridization with chromosome-specific DNA probes, facilitate the confirmation of presumed chromosomal aberrations with high sensitivity and specificity.ResultsOut of 30 cases 29 represent molecular alteration. About 70% of cases presented chromosome 17 polysomy and only 20% of cases had chromosome 17 monosomy. 58% of samples revealed p53 gene amplification and 37% of them showed p53 deletion.DiscussionHigh frequency of correlation between molecular changes in chromosome 17 and p53 gene with OSCC indicates towards their critical role in development of this disease.
Source: Journal of the Anatomical Society of India - Category: Anatomy Source Type: research