In vitro potentiation of carbapenems with tannic acid against carbapenemase ‐producing enterobacteriaceae: exploring natural products as potential carbapenemase inhibitors

ConclusionTA inhibited both MBLs and SBLs by targeting their hydrophobic sites. Moreover, TA had a stronger binding affinity for MBLs than SBLs as the MBLs, specifically VIM ‐1 (−43·7220 ± 0·4513 kcal mol−1) and NDM ‐1(−44·2329 ± 0·3806 kcal mol−1), interact with a larger number of their catalytic active ‐site residues than that of OXA‐48 (−22·5275 ±  0·1300 kcal mol−1) and KPC ‐2 (−22·1164 ± 0·0111 kcal mol−1).Significance and Impact of the StudyTannic acid or its analogues could be  developed into carbapenemase‐inhibiting adjuvants to restore carbapenem activity in CRE infections, save many lives and reduce healthcare associated costs.

Source: Journal of Applied Microbiology - November 23, 2018 Category: Microbiology Authors: A.M. Somboro, J. Osei Sekyere, D.G. Amoako, H.M. Kumalo, R. Khan, L.A. Bester, S.Y. Essack Tags: Original Article Source Type: research