Comparison of rheumatoid arthritis (RA) and osteoarthritis (OA) based on microarray profiles of human joint fibroblast ‐like synoviocytes

This study revealed the similar and different mechanisms of FLSs and different biomarkers that might with important regulatory effects on RA and OA. In OA, FLSs played an inflammatory role through TNF signalling pathway, targeting SELE, SERPINE1, and NFKBIA. Although TNF signalling pathway was also involved in the synovitis of RA, chemokine signalling pathway was a crucial pathway in mediating FLSs migration, invasion, and release of chemotaxis. CCR5, CCR7, CXCR4, CCL5, and CCR4 might be keys genes in RA. We expect that our results will bring more comprehensively understanding between RA and OA for researchers.

Source: Cell Biochemistry and Function - November 23, 2018 Category: Biochemistry Authors: Peian Cai, Tongmeng Jiang, Bo Li, Xiong Qin, Zhenhui Lu, Yiguan Le, Chong Shen, Yifeng Yang, Li Zheng, Jinmin Zhao Tags: RESEARCH ARTICLE Source Type: research