The cellular and molecular mechanism of glutaraldehyde ‐didecyldimethylammonium bromide as a disinfectant against Candida albicans

ConclusionsGlutaraldehyde ‐didecyldimethylammonium bromide disinfectedC. albicans through distorting cell membrane integrity and permeability, disturbing the intracellular homeostasis by intracellular substances leakage, especially K+, Mg2+, ATP and protein, causing electrolyte imbalance of mitochondria, changing DNA structure, which finally led to cell death.Significance and Impact of the StudyThis study focused on the cellular and molecular mechanism of GD as a disinfectant againstC. albicans. It is important to provide theoretical support to GD againstCandida albicans in practical application.

Source: Journal of Applied Microbiology - November 21, 2018 Category: Microbiology Authors: W. Lin, D. Yuan, Z. Deng, B. Niu, Q. Chen Tags: Original Article Source Type: research