Circulating miRNA ‐150‐5p is associated with immune‐mediated early β‐cell loss in a humanized mouse model

ConclusionsOur data demonstrated that immune ‐related miRNAs are associated with human islet xenograft rejection in mice. miR‐150‐5p is increased in human islet graft and in the circulation during islet xenograft rejection and β‐cell destruction prior to hyperglycemia and may be an early biomarker for islet xenograft rejection.

Source: Xenotransplantation - November 21, 2018 Category: Transplant Surgery Authors: Regan Roat, Md Munir Hossain, Jenica Christopherson, Colette Free, Claudiane Guay, Romano Regazzi, Zhiguang Guo Tags: ORIGINAL ARTICLE Source Type: research