Fetal human leukocyte antigen-C and maternal killer-cellimmunoglobulin-like receptors in cases of severe preeclampsia
The pathogenesis of preeclampsia may involve inadequate trophoblast invasion caused by excessive inhibition of uterine natural killer cells (uNK) by extravillous trophoblast cells (EVT). This may be the result of a combination of maternal killer-cell immunoglobin-like receptor (KIR) AA genotype and fetal human leukocyte antigen-C2 (HLA-C2) genotype. A few studies have reported a significantly increased frequency of the maternal KIR AA/fetal HLA-C2 combination in cases of preeclampsia compared to controls.
Source: Placenta - Category: Reproduction Medicine Authors: Tine Graakj ær Larsen, Rinat Hackmon, Daniel E. Geraghty, Thomas Vauvert F. Hviid Source Type: research
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