A 5 α‐reductase (SRD5A2) polymorphism is associated with serum testosterone and sex hormone–binding globulin in men, while aromatase (CYP19A1) polymorphisms are associated with oestradiol and luteinizing hormone reciprocally

ConclusionsA 5 α‐reductase polymorphism predicts circulating T and SHBG, while aromatase polymorphisms predict E2 and LH in reciprocal fashion. Age and aromatase polymorphisms interact to affect E2 and LH. How these functional polymorphisms impact on male reproductive and general health outcomes requires furthe r study.

https://onlinelibrary.wiley.com/doi/abs/10.1111/cen.13885?af=R

Source: Clinical Endocrinology - November 19, 2018 Category: Endocrinology Authors: Bu B. Yeap, Matthew W. Knuiman, David J. Handelsman, Ken K. Y. Ho, Jennie Hui, Mark L. Divitini, Gillian M. Arscott, Brendan McQuillan, Joseph Hung, John P. Beilby Tags: ORIGINAL ARTICLE Source Type: research