Aloysia citriodora Palau (lemon verbena) for insomnia patients: A randomized, double ‐blind, placebo‐controlled clinical trial of efficacy and safety
This study was carried out to assess the efficacy ofA. citriodora in patients with insomnia. One hundred patients were randomly divided into two groups ofA. citriodora (total essential oil 1.66 mg/10 ml and total amount of flavonoid in terms of quercetin 3.22 mg/10 ml of the syrup) and placebo. They were advised to use 10 cc of the syrups; an hour before the bedtime for a period of 4 weeks. Participants were assessed using Pittsburgh Sleep Quality Index (PSQI) and Insomnia Severity Index (ISI) questionnaires at the baseline and then 2 and 4 weeks after the enrollment. Mean scores of global PSQI and its four components including sleep latency, habitual sleep efficiency, daytime dysfunction, and subjective sleep quality and also ISI score in theA. citriodora group improved significantly after 4 weeks of treatment when compared with the placebo group (p < 0.001, for all of them). Also, improvement of global score of PSQI and ISI was observed in the intervention group as compared with the placebo group, 2 weeks after the enrollment (p < 0.001). The results of this study showed that oral intake ofA. citriodora can be suggested as a complementary treatment for patients with insomnia.
Source: Phytotherapy Research - Category: Biochemistry Authors: Farshid Afrasiabian,
Mehran Mirabzadeh Ardakani,
Khaled Rahmani,
Nammam Ali Azadi,
Zahra Banafsheh Alemohammad,
Reza Bidaki,
Mehrdad Karimi,
Majid Emtiazy,
Mohammad Hashem Hashempur Tags: RESEARCH ARTICLE Source Type: research
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