Region ‐specific control of microglia by adenosine A2A receptors: uncoupling anxiety and associated cognitive deficits in female rats

We report that iuDEX impaired recognition memory and deteriorated neuronal synchronization between mPFC and dHIP. These functional deficits are paralleled by microglia hyper ‐ramification in the dHIP and decreased ramification in the mPFC, showing a heterogeneous remodeling of microglia morphology, both postnatally and at adulthood in different brain regions, that differently affect mood and cognition. The chronic blockade of adenosine A2A receptors (A2AR), which are core regulators of microglia morphology and physiology, ameliorated the cognitive deficits, but not the anxiety ‐like behavior. Notably, A2AR blockade rectified both microglia morphology in the dHIP and the lack of mPFC ‐dHIP synchronization, further heralding their role in cognitive function.

Source: Glia - November 21, 2018 Category: Neurology Authors: Joana Mendes Duarte, Rita Gaspar, Liliana Caetano, Patr ícia Patrício, Carina Soares‐Cunha, António Mateus‐Pinheiro, Nuno Dinis Alves, Ana Rita Santos, Samira G Ferreira, Vanessa Sardinha, João Filipe Oliveira, Carlos Fontes‐Ribeiro, Tags: RESEARCH ARTICLE Source Type: research