Updated Meta-analysis on the Closure of Patent Foramen Ovale in Reduction of Stroke Rates: the DEFENSE-PFO Trial Does not Change the Scenario
Objective: We aimed to analyze whether patent foramen ovale (PFO) closure reduces the
risk of stroke, assessing also some safety outcomes after the publication of
a new trial.Introduction: The clinical benefit of closing a PFO has been an open question, so it is
necessary to review the current state of published medical data in regards
to this subject.Methods: MEDLINE, EMBASE, CENTRAL/CCTR, SciELO, LILACS, Google Scholar and reference
lists of relevant articles were used to search for randomized controlled
trials (RCTs) that reported any of the following outcomes: stroke, death,
major bleeding or atrial fibrillatio ...
Source: Brazilian Journal of Cardiovascular Surgery - Category: Cardiology Source Type: research
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