Autocrine VEGF signalling on M2 macrophages regulates PD ‐L1 expression for immunomodulation of T cells

In conclusion, our findings provide a novel biological basis to support the current successful strategy using combined VEGF/PD ‐1 signalling blockade in cancer therapy.

Source: Journal of Cellular and Molecular Medicine - November 20, 2018 Category: Molecular Biology Authors: Yin ‐Siew Lai, Rika Wahyuningtyas, Shin‐Peir Aui, Ko‐Tung Chang Tags: ORIGINAL ARTICLE Source Type: research