Microsponge: An emerging drug delivery strategy

Abstract Hit, Lead& Candidate DiscoveryMicrosponges are the spherical particles ranging from 5 to 300  μm in size. These are further made up of clusters of smaller spheres. They are designed for delivering the drug efficiently at a comparatively lesser dose and enhancing the stability, modifying the drug release profile and minimizing the side effects. Microsponge drug delivery system decrease tr ansdermal invasion of the active ingredient into the skin while increasing the time the drug remains on the skin surface or within the epidermis. Preparation of the microsponges includes two techniques: Liquid–liquid suspension polymerization and Quasi‐emulsion solvent diffusion method. Their ch aracterization and evaluation can be done in many ways like particle‐size measurement and porosity, morphology, true density determination, analyzing the rheological properties, and dissolution studies. Present work focuses on the detailed study of the microsponge drug delivery system. This will h elp the reader to get all the information regarding the microsponge delivery systems.
Source: Drug Development Research - Category: Drugs & Pharmacology Authors: Tags: OVERVIEW Source Type: research