PYY(3-36) and exendin-4 reduce food intake and activate neuronal circuits in a synergistic manner in mice
Peptide YY(3-36) ((PYY(3-36)) and glucagon like peptide 1 (GLP-1) in combination reduce food intake and body weight in an additive or synergistic manner in animal models and in humans. Nevertheless, the mechanisms behind are not completely understood. The present study aims to investigate the effect of combining PYY(3-36) and the GLP-1 receptor agonist exendin-4 (Ex4) by examining acute food intake and global neuronal activation as measured by c-fos in C57BL/6 J mice. An additive reduction in food intake was found 1.5 h after s.c dosing with the combination of PYY(3-36) (200 μg/kg) and Ex4 (2.5 μg/kg).
Source: Neuropeptides - Category: Neuroscience Authors: Marina Kjaergaard, Casper Bo Gravesen Salinas, Jens F. Rehfeld, Anna Secher, Kirsten Raun, Birgitte S. Wulff Source Type: research