Resting ‐state functional connectivity after concussion is associated with clinical recovery

AbstractThere has been a recent call for longitudinal imaging studies to better characterize the time course of physiological recovery following sport ‐related concussion (SRC) and its relationship with clinical recovery. To address this, we evaluated changes to resting‐state functional connectivity (rs‐FC) of the whole‐brain network following SRC and explored associations between rs‐FC and measures of clinical outcome. High school and c ollegiate football athletes were enrolled during preseason. Athletes that suffered SRC (N =  62) were assessed across the acute (within 48 hr) and sub‐acute (days 8, 15, and 45) phases. Matched football athletes without concussion served as controls (N =  60) and participated in similar visits. Multi‐band resting‐state fMRI was used to assess whole‐brain rs‐FC at each visit using network‐based statistic and average nodal strength from regions of interest defined using a common whole‐brain parcellation. Concussed athletes had elevated s ymptoms, psychological distress, and oculomotor, balance, and memory deficits at 48 hr postconcussion relative to controls, with diminished yet significant elevations in symptoms and psychological distress at 8 days. Both rs‐FC analyses showed that concussed athletes had a global increase in c onnectivity at 8 days postconcussion relative to controls, with no differences at the 48‐hr, 15‐day, or 45‐day visits. Further analysis revealed the group effect at the 8‐day ...
Source: Human Brain Mapping - Category: Neurology Authors: Tags: RESEARCH ARTICLE Source Type: research