Dynamic Changes in Innate Immune Responses During Direct Acting Antiviral Therapy for HCV Infection

In conclusion, PrOD+R for 12 weeks was well‐tolerated with no VF. Our data demonstrate dynamic alterations in innate immune profiles during highly‐potent IFN‐free DAA therapy. The downregulation of ISG post‐therapy s uggests reversal of the “exhausted” ISG phenotype following SVR, and the rise in ISGs and IFNα/IFN‐responsive chemokines late during therapy suggests resetting of IFN responsiveness that may be relevant in determining duration of or immunological sequelae from DAA therapy, including HBV react ivation.This article is protected by copyright. All rights reserved.

Source: Journal of Viral Hepatitis - November 19, 2018 Category: Infectious Diseases Authors: Jacinta A. Holmes, Charles Carlton ‐Smith, Arthur Y. Kim, Emily O. Dumas, Joelle Brown, Jenna L. Gustafson, Georg M. Lauer, Sakuni T. Silva, Maxwell Robidoux, Daniel Kvistad, Nadia Alatrakchi, Pierre Tonnerre, Daniel E. Cohen, Hongtao Zhang Tags: Original Paper Source Type: research