Fate of two types of cerebellar graft in wild type and cerebellar mutant mice

Publication date: January 2014 Source:Journal of Applied Biomedicine, Volume 12, Issue 1 Author(s): Miroslava Čedíková , Zbyněk Houdek , Václav Babuška , Vlastimil Kulda , František Vožeh , Nicolas Zech , Lenka Černá , Kristýna Krakorová , Milena Králíčková , Jan Cendelín The possibility of regeneration in a damaged central nervous system (CNS) is limited and therapy of CNS diseases accompanied with neuronal loss is problematic. Lurcher (Lc) mutant mice represent a model for olivocerebellar degeneration. Heterozygotes suffer from a complete loss of cerebellar Purkinje cells and a secondary reduction of granule cells and inferior olive neuron number.
Source: Journal of Applied Biomedicine - Category: Biotechnology Source Type: research