HPLC analysis and antimicrobial, antimycobacterial and antiviral activities of Tabernaemontana catharinensis A. DC

Publication date: Available online 4 February 2014 Source:Journal of Applied Biomedicine Author(s): Aline Augusti Boligon , Mariana Piana , Thaís Felli Kubiça , Débora Nunes Mario , Tanise Vendruscolo Dalmolin , Pauline Cordenonsi Bonez , Rudi Weiblen , Luciane Lovato , Sydney Hartz Alves , Marli M.A. Campos , Margareth Linde Athayde Antimicrobial, antimycobacterial and antiviral activities of crude extracts, fractions and subfractions of Tabernaemontana catharinensis were evaluated. Best antimicrobial results occurred with the dichloromethane (DCM) and butanolic (NB) fractions against Staphylococcus aureus, Micrococcus sp., Enterococcus faecalis and Bacillus subtilis (minimal inhibitory concentration, MIC=31.25–1000μg/mL). Considering the Gram-negative bacteria, only NB fraction was effective against Proteus mirabilis and Aeromonas sp. (MIC=62.5μg/mL and 250μg/mL, respectively). In addition, the fungi Candida albicans, Candida glabrata, Cryptococcus neoformans, Saccharomyces cerevisiae, Aspergillus flavus and Aspergillus fumigatus were particularly vulnerable for DCM fraction (MIC=31.25–1000μg/mL). The fractions and subfractions were effective against Mycobacterium smegmatis (MIC=19.53–156.25μg/mL). DCM (selectivity index – SI=77.92), ethyl acetate (EA) (SI=40.27) and NB (SI=28.97) fractions from the leaves exhibited a potential antiviral activity toward Herpes Simplex Virus type 1 whereas DCM2 subfraction from leaves (SI=12.28) and alkaloidal ...
Source: Journal of Applied Biomedicine - Category: Biotechnology Source Type: research