Diethyldithiocarbamate complexes with metals used as food supplements show different effects in cancer cells

In this study, we demonstrate the effect of synthetic complexes of disulfiram with four various metals (Mn, Fe, Cr and Cu) used as food supplements. These complexes may be spontaneously formed in the blood during the use of disulfiram with divalent metals and thus may suppress the growth of cancer in vivo. The cytotoxic effect of the compounds and the compounds’ ability to inhibit the cellular proteasome were tested in the osteosarcoma cell line U2OS. After 48h, copper and manganese complexes exhibited cytotoxic effect on the cell line, in sharp contrast to both iron and chromium complexes.
Source: Journal of Applied Biomedicine - Category: Biotechnology Source Type: research