Metformin attenuates the effect of Staphylococcus aureus on airway tight junctions by increasing PKC ζ‐mediated phosphorylation of occludin
This study demonstrates that metformin improves TJ barrier function by promoting the abundance and assembly of full length occludin at the TJ and that this process involves phosphorylation of the protein via an AMPK‐PKCζ pathway.
Source: Journal of Cellular and Molecular Medicine - Category: Molecular Biology Authors: Kameljit K. Kalsi,
James P. Garnett,
Wishwanath Patkee,
Alexina Weekes,
Mark E. Dockrell,
Emma H. Baker,
Deborah L. Baines Tags: ORIGINAL ARTICLE Source Type: research
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