Effect of regular exercise on leukocyte function in young and middle-aged women

Publication date: December 2013 Source:Journal of Exercise Science & Fitness, Volume 11, Issue 2 Author(s): Vinicius C. Santos , Izildinha R. Procida , Evelin A.A. Zicolau , Elaine Hatanaka , Cristina Borges-Silva , Tania C. Pithon-Curi , Maria F. Cury-Boaventura The purpose of this study was to investigate the effects of regular training on lymphocyte proliferation, plasma cytokine levels, and parameters of neutrophil and lymphocyte death in young women (YW) and middle-aged women (MAW). Thirteen untrained YW, 12 untrained MAW, 12 trained YW, and 17 trained MAW participated in this investigation. The characteristics measured were lymphocyte proliferation, plasma cytokine levels, and parameters of neutrophil and lymphocyte death (viability, DNA fragmentation, phosphatidylserine externalization, and mitochondrial depolarization). The lymphocyte proliferation of untrained MAW was 30% lower than that of untrained YW. The YW had a significant decrease in the viability of lymphocytes and neutrophil compared with that of MAW (p < 0.05). The training prevented the loss of neutrophil viability observed in YW (p < 0.05). By contrast, regular exercise caused increases in lymphocyte apoptosis in both YW and MAW (p < 0.05) and neutrophil apoptosis in MAW only (p < 0.05). The plasma concentration of interleukin-1ra (IL-1ra) was increased (fourfold) by regular activity in YW, and the IL-2 plasma levels were increased (twofold) in the YW...
Source: Journal of Exercise Science and Fitness - Category: Sports Medicine Source Type: research