The antitumor effects of entinostat in ovarian cancer require adaptive immunity

CONCLUSIONSIn the current murine ovarian cancer model, entinostat treatment enhances beneficial immune responses. Moreover, these antitumor effects of entinostat are dependent on an intact immune system. Future studies combining entinostat with checkpoint inhibitors or other immunomodulatory agents may achieve more durable antitumor responses in patients with ovarian cancer.

Source: Cancer - November 13, 2018 Category: Cancer & Oncology Authors: Haller J. Smith, Tyler R. McCaw, Angelina I. Londono, Ashwini A. Katre, Selene Meza ‐Perez, Eddy S. Yang, Andres Forero, Donald J. Buchsbaum, Troy D. Randall, J. Michael Straughn, Jr, Lyse A. Norian, Rebecca C. Arend Tags: Original Article Source Type: research