Treatment-resistant depression: A systematic review of systematic reviews

The objective of this research study was to assess pharmacological, somatic and/or psychological treatments in adults with a diagnosis of major depressive disorder who have not responded to at least one course of antidepressant medication. We conducted a systematic review to identify systematic scientific reviews and meta-analyses on treatment-resistant depression (TRD) published until February 2012. Of the sixty studies selected, sixteen met the inclusion criteria and were therefore included in the review. We considered eight main themes, including the definition of TRD, long-term results, and different treatment strategies, including so-called somatic therapies. Based on the review, the definition of TRD should be standardized in order to achieve a shared conceptualization of this disorder. This would allow a better understanding among clinicians and researchers in the field, promoting a homogeneous research methodology and thus leading to more reliable and comparable results. This essential conceptual clarification would also have a positive impact on patients with TRD, their families, and social and health systems. El objetivo de esta investigación es analizar la literatura científica sobre los tratamientos farmacológicos, somáticos y/o psicológicos en adultos con diagnóstico de un trastorno depresivo mayor que no han respondido al menos a un tratamiento con antidepresivos. Se llevó a cabo una revisión sistemática sin limitación temporal para identificar las r...
Source: International Journal of Clinical and Health Psychology - Category: Psychiatry & Psychology Source Type: research