Kinetics of del(7q) driven leukemogenesis in a patient with JAK2 V617F and TET2 mutated chronic myeloproliferative neoplasm

Publication date: 2013 Source:Leukemia Research Reports, Volume 2, Issue 2 Author(s): Laura Laine Herborg , Line Nederby , Eigil Kjeldsen , Kirsten Grønbæk , Peter Hokland , Maria Hansen , Marcus Celik Hansen , Anne Stidsholt Roug Chronic myeloid neoplasms have susceptibility to transform into acute myeloid leukemia due to attainment of additional molecular lesions. We here describe the kinetics of a del(7q) driven leukemogenesis in a patient with multiple TET2 mutations and JAK2 V617F mutated chronic myeloproliferative neoplasm. The del(7q) emerged in the accelerated phase of disease, which was preceded by a lag phase of almost three years with normalized peripheral blood cell counts. Our results reveal that the del(7q), independently of other lesions, acts as a leukemic driver in this patient and that the stable long-lasting normalization of peripheral blood cell values concealed pending transformation.
Source: Leukemia Research Reports - Category: Hematology Source Type: research