Amino acid and lipid profiles following pig ‐to‐primate liver xenotransplantation

This report aims to further investigate the post‐LXT lipid and amino acid metabolism profile in our longest surviving recipients (25 and 29 da ys). Experimental samples and control samples, consisting of pre‐transplant porcine and baboon serum and plasma, were analyzed for standard lipid profiles and for amino acid levels. Lipid profiles of LXT recipients remained stable following xenotransplantation compared to donor porcine baseline le vels. Amino acid concentrations also remained similar to baseline controls, with the exception of a 3‐foldincrease inl‐ornithine and more than a 10‐folddecrease inl‐arginine post‐transplant when compared to both porcine and baboon baseline levels. The observed changes inl‐arginine are consistent with prior studies investigating the effects of graft preservation injury following liver transplantation. These results indicate that the porcine liver can maintain most biochemical profiles stably post‐operatively in baboons and suggest that arginine supplementation po st‐LXT may potentially be useful for further prolongation of xenograft survival.
Source: Xenotransplantation - Category: Transplant Surgery Authors: Tags: BRIEF COMMUNICATION Source Type: research