Cachexia does not induce loss of myonuclei or muscle fibres during xenografted prostate cancer in mice

ConclusionThe data suggest that the cachexia induced by xenografted prostate tumours induces a pronounced atrophy not accompanied by a loss of myonuclei or a loss of muscle fibres. Thus, stem cell related treatment might be redundant, and the quest for treatment options should rather focus on intervening with intracellular pathways regulating muscle fibre size.

Source: Acta Physiologica - November 16, 2018 Category: Physiology Authors: Ivan Myhre Winje, Xia Sheng, Kenth ‐Arne Hansson, Andreas Solbrå, Simen Tennøe, Fahri Saatcioglu, Jo Christiansen Bruusgaard, Kristian Gundersen Tags: REGULAR PAPER Source Type: research