Structure analysis of transposons carrying the aac(6 ′)-aph(2″) gene in Enterococcus faecalis isolated in Beijing, China, and comparison of their transfer efficiency

Enterococcus faecalis is the most clinically relevant isolate in the Enterococcus genus and is increasingly recognised as an important cause of nosocomial infections, especially in intensive care units. Severe enterococcal infections are usually treated using a combination of a cell-wall-active agent ( β-lactam or vancomycin) with an aminoglycoside (typically gentamicin). However, this synergistic bactericidal activity was abolished by the emergence of high-level gentamicin resistance (HLGR). Enterococcus faecalis with HLGR was first reported clinically in France in 1979 [1] and was quickly follo wed by numerous reports from a variety of geographical areas [2–8].
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Source Type: research