High PD ‐L1 expression in the tumour cells did not correlate with poor prognosis of patients suffering for oral squamous cells carcinoma: A meta‐analysis of the literature

This study aimed to investigate, through a meta‐analysis, a potential correlati on between PD‐L1 expression and the prognostic outcomes in patients with oral squamous cell carcinoma.Materials and methodsThe studies were identified by searching PubMed, SCOPUS, Web of Science and were assessed by two of the authors. After the selection process, 11 articles met eligibility criteria and were included in the meta ‐analysis. Quality assessment of studies was performed according to the REMARK guidelines, and the risk of biases across studies was investigated through Q andI2 tests. Meta ‐analysis was performed to investigate the association between the PD‐L1 expression either overall survival (OS), disease‐free survival (DFS), disease‐specific survival (DSS), gender and lymph node metastasis.ResultsA total of 1060 patients were analysed in the 11 studies included in the meta ‐analysis. Pooled analysis revealed that the expression of PD‐L1 did not correlate with poor OS (HR, 0.60; 95% CI: [0.33, 1.10];P = 0.10), DFS (HR, 0.62; 95% CI: [0.21, 1.88];P = 0.40), DSS (HR, 2.05; 95% CI: [0.53, 7.86];P = 0.29 and lymph node metastasis (HR, 1.15; 95% CI: [0.74, 1.81];P = 0.53). Furthermore, results of the meta‐analysis showed that high expression of PD‐L1 is two times more frequent in female patients (OR, 0.5; 95% CI: [0.36, 0.69];P  <  0.0001) compared to males. For all the three outcomes analysed, a high rate of heterogeneity was detected (I2  >  50%)...
Source: Cell Proliferation - Category: Cytology Authors: Tags: REVIEW ARTICLE Source Type: research