AP2a enhanced the osteogenic differentiation of mesenchymal stem cells by inhibiting the formation of YAP/RUNX2 complex and BARX1 transcription

ConclusionsOur discoveries revealed that AP2a may regulate the osteogenic differentiation in an indirect way through competing with RUNX2 to relieve the RUNX2 activity which inhibited by YAP, and also in a direct way via targeting the BARX1 and directly repressed its transcription. Thus, our discoveries shed new light on the mechanism of direct differentiation of MSCs and provide candidate targets for improving the osteogenic differentiation and enhancing bone tissue regeneration.

Source: Cell Proliferation - November 15, 2018 Category: Cytology Authors: Xiao Lin, Haoqing Yang, Lijun Wang, Wenzhi Li, Shu Diao, Juan Du, Songlin Wang, Rui Dong, Jun Li, Zhipeng Fan Tags: ORIGINAL ARTICLE Source Type: research