Drosophila glia: Few cell types and many conserved functions

• Many glial functions are evolutionarily conserved• Drosophila has six functionally distinct glial subtypes, including one PNS specific form• Drosophila glia can be used to model human diseases AbstractGlial cells constitute without any dispute an essential element in providing an efficiently operating nervous system. Work in many labs over the last decades has demonstrated that neuronal function, from action potential generation to its propagation, from eliciting synaptic responses to the subsequent postsynaptic integration, is evolutionarily highly conserved. Likewise, the biology of glial cells appears conserved in its core elements and therefore, a deeper understanding of glial cells is expected to benefit from analyzing model organisms such asDrosophila melanogaster. Drosophila is particularly well suited for studying glial biology since in the fly nervous system only a limited number of glial cells exists, which can be individually identified based on position and a set of molecular markers. In combination with the well ‐known genetic tool box an unprecedented level of analysis is feasible, that not only can help to identify novel molecules and principles governing glial cell function but also will help to better understand glial functions first identified in the mammalian nervous system. Here we review the curre nt knowledge on Drosophila glia to spark interest in using this system to analyze complex glial traits in the future.
Source: Glia - Category: Neurology Authors: Tags: REVIEW ARTICLE Source Type: research