Traditional Chinese medicine as targeted treatment for epithelial ‐mesenchymal transition‐induced cancer progression

This review summarize the crucial signaling pathways associated with the epithelial ‐mesenchymal transition (EMT) process in cancer patients and discuss the interconnections between EMT and other molecular factors (such as cancer stem cells [CSCs], vasculogenic mimicry [VM] and the tumor‐related immune microenvironment). The authors attempt to identify common regulators that mi ght be potential therapeutic targets to thereby optimize tumor treatment. In addition, the article also outlines recent research on traditional Chinese medicine (TCM) approaches that target EMT which will be helpful on the further study of TCM on EMT in cancer AbstractThe epithelial ‐mesenchymal transition (EMT) program, which loosens cell‐cell adhesion complexes, endows cells with enhanced migratory and invasive properties. Furthermore, this process facilitates both the development of drug resistance and immunosuppression by tumor cells, which preclude the successful treat ment of cancer. Recent research has demonstrated that many signaling pathways are involved in EMT progression. In addition, cancer stem cells (CSCs), vasculogenic mimicry (VM) and the tumor‐related immune microenvironment all play important roles in tumor formation. However, there are few reports on the relationships between EMT and these factors. In addition, in recent years, traditional Chinese medicine (TCM) has developed a unique system for treating cancer. In this review, we summarize the crucial signaling pathways as...
Source: Journal of Cellular Biochemistry - Category: Biochemistry Authors: Tags: VIEW POINTS Source Type: research