Parkinsonism due to A53E α‐synuclein gene mutation: Clinical, genetic, epigenetic, and biochemical features

Conclusions: A53E as a cause of parkinsonism is not restricted to Finnish individuals. DNA methylation may contribute to disease age at onset. A53E enriches α‐synuclein oligomers and fibrils dependent on the phosphorylation state.

Source: Movement Disorders - November 13, 2018 Category: Neurology Authors: Marina Picillo, Karlo J. Lizarraga, Erik L. Friesen, Hien Chau, Ming Zhang, Christine Sato, Grace Rooke, Renato P. Munhoz, Ekaterina Rogaeva, Paul E. Fraser, Suneil K. Kalia, Lorraine V. Kalia Tags: Brief Report Source Type: research