High long ‐term mortality after incident status epilepticus in adults: Results from a population‐based study

SummaryObjectiveTo determine annual incidence, etiology, severity, and short ‐ and long‐term mortality of first‐time, nonanoxic status epilepticus (SE) in adults in a population‐based retrospective cohort study.MethodsWe systematically identified all episodes of SE in the year 2014 on the island of Funen. Patients with SE due to anoxia, patients with recurrent SE, and patients<18  years old were excluded. Nonconvulsive SE in coma was diagnosed according to the Salzburg criteria. Etiology, semiology, modified Rankin Scale (mRS) at discharge, survival, and the Status Epilepticus Severity Score were retrospectively determined from patients’ records. Patients with first‐tim e nonanoxic SE diagnosed during 2008‐2013 from our database (n = 88) were used to confirm the results.ResultsThe incidence of first ‐time, nonanoxic SE in 2014 was 10.7/100 000 persons at risk (n = 41). Median Status Epilepticus Severity Score was 3; in‐hospital mortality was 24.4%. After median follow‐up of 39.2 months, 53.7% of the patients had died (age‐ and gender‐adjusted mortality rate of 5.2/100 000). Morta lity stabilized 2 years after diagnosis. Analysis of the cohort from 2008‐2013 confirmed stabilization of survival after 2‐3 years and the high mortality 2 years after discharge. When correcting for acute symptomatic causes, the in‐hospital mortality was 16.7% and 46.7% at follow‐up (crud e mortality rate of nonhypoxic and nonacute symptomatic SE = 3.5/10...
Source: Epilepsia - Category: Neurology Authors: Tags: FULL ‐LENGTH ORIGINAL RESEARCH Source Type: research