Mice with epidermal filaggrin deficiency show increased immune reactivity to nickel

ConclusionsThese findings suggest that the increased nickel responsiveness associated with epidermal filaggrin deficiency is mediated by a combination of increased nickel penetration and the steady ‐state inflammation found in the skin of filaggrin‐deficient mice.

Source: Contact Dermatitis - November 13, 2018 Category: Dermatology Authors: Trine H. Petersen, Mia H. Jee, Anne ‐Sofie Ø. Gadsbøll, Jonas D. Schmidt, Jens J. Sloth, Gregory F. Sonnenberg, Carsten Geisler, Jacob P. Thyssen, Charlotte M. Bonefeld Tags: ORIGINAL ARTICLE Source Type: research