Pravastatin improves fetal survival in mice with a partial deficiency of heme oxygenase-1

Statins induce heme oxygenase-1 (HO-1) expression in vitro and in vivo. Low HO-1 expression is associated with pregnancy complications, e.g. preeclampsia and recurrent miscarriages. Here, we investigated the effects of pravastatin on HO-1 expression, placental development, and fetal survival in mice with a partial HO-1 deficiency.

Source: Placenta - November 14, 2018 Category: Reproduction Medicine Authors: Abraham Tsur, Flora Kalish, Jordan Burgess, Nihar R. Nayak, Hui Zhao, Kerriann M. Casey, Maurice L. Druzin, Ronald J. Wong, David K. Stevenson Source Type: research