Repurposing azithromycin and rifampicin against Gram-negative pathogens by combination with peptide potentiators

The objective of this study was to identify peptides that at low concentrations induce susceptibility to these antibiotics in multidrug-resistant (MDR) Gram-negative strains of clinical relevance. A pairwise screening of 34 diverse peptides and four antibiotics (erythromycin, linezolid, rifampicin and vancomycin) with primary activity against Gram-positive bacteria identified four peptides that at sub-micromolar concentrations conferred susceptibility to rifampicin or erythromycin in Escherichia coli ATCC 25922.
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Tags: Short Communication Source Type: research