Glucagon infusion alters the hyperpolarized 13C ‐urea renal hemodynamic signature

This study demonstrate that hyperpo larized13C ‐urea enables monitoring of renal urinary excretion effectsin vivo. Renal urea handling is central to the urine concentrating mechanism, and as such the ability to image urea transport in the kidney is an important potential imaging biomarker for renal functional assessment. Glucagon levels associated with changes in dietary protein intake have been shown to influence renal urea handling; however, the exact mechanism has still to be fully understood. Here we investigate renal function and osmolite distribution using [13C,15N] urea dynamics and23Na distribution before and 60  min after glucagon infusion in six female rats.Glucagon infusion increased the renal [13C,15N] urea mean transit time by 14%, while no change was seen in the sodium distribution, glomerular filtration rate or oxygen consumption. This change is related to the well ‐known effect of increased urea excretion associated with glucagon infusion, independent of renal functional effects. This study demonstrates for the first time that hyperpolarized13C ‐urea enables monitoring of renal urinary excretion effects in vivo.

Source: NMR in Biomedicine - November 14, 2018 Category: Radiology Authors: Haiyun Qi, Christian Østergaard Mariager, Per Mose Nielsen, Marie Schroeder, Jakob Lindhardt, Rikke Nørregaard, Janet D. Klein, Jeff M. Sands, Christoffer Laustsen Tags: RESEARCH ARTICLE Source Type: research