Weight gain as a predictor of frontal and temporal lobe volume loss in bipolar disorder: a prospective MRI study

ConclusionsThese are the first prospective data on weight gain and neuroprogression in BDI. CSWG predicted neuroprogression, and neuroprogression predicted a worse clinical illness course. Trials of weight loss interventions are needed to confirm the causal direction of the weight gain ‐neuroprogression relationship, and to determine whether weight loss is a disease‐modifying treatment.This article is protected by copyright. All rights reserved.

Source: Bipolar Disorders - November 13, 2018 Category: Psychiatry Authors: David J. Bond, Wayne Su, William G. Honer, Taj Dhanoa, Tegan Batres ‐y‐Carr, Susanne S. Lee, Ivan J. Torres, Raymond W. Lam, Lakshmi N. Yatham Tags: Original Article Source Type: research