Ex vivo evaluation of the efficacy of canine fresh ‐frozen plasma thawed using a microwave plasma defroster

This study was undertaken to assess the efficacy of a commercial MPD for the rapid thawing of canine FFP.Study DesignTwenty ‐three units (twelve 120 mL and eleven 240 mL) of canine FFP were thawed using an MPD. Time‐to‐thaw and pre‐ and postthawing temperatures of the units were measured. Clotting factor activities (factors II, V, VII, VIII, IX, X, and von Willebrand factor), fibrinogen concentrations, prothrombi n times, and activated partial thromboplastin times were measured.Key FindingsThe evaluated MPD effectively thaws plasma quickly for both 120 mL units (2.7 ± 0.08 min) and 240 mL units (3.9 ± 0.15 min) while maintaining clinically relevant activities of clotting factors and fibrinogen concentration. While some measurements of factor VIII activity fell below the reference interval, none fell below 40%. One 240 mL unit had von Willebrand factor activit y<70%. There was no evidence of excessively heated plasma to indicate a safety concern.SignificanceThe MPD evaluated in this study provides a useful means to rapidly thaw canine FFP for correction of factor ‐deficient coagulopathy.
Source: Journal of Veterinary Emergency and Critical Care - Category: Veterinary Research Authors: Tags: Brief Clinical Communication Source Type: research