A pilot study documenting increased thrombin generation following abrupt withdrawal of heparin therapy in healthy dogs

ConclusionTAT results suggest that a transient increase in thrombin generation developed 12 hours after withdrawal of UFH therapy. Though clot kinetics were rapid compared to baseline beginning 30 hours after heparin withdrawal, a return to baseline was not documented. Future studies are warranted to determine the clinical relevance of these results and to evaluate the effect of UFH withdrawal in critically ill animals.
Source: Journal of Veterinary Emergency and Critical Care - Category: Veterinary Research Authors: Tags: Original Study Source Type: research