Long noncoding RNA uc.4 inhibits cell differentiation in heart development by altering DNA methylation

In this study, methylated DNA immunoprecipi tation was performed to identify the different expression levels of methylation regions. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were also performed to identify the possible biological process and pathway that uc.4 may join, associated with Rap1 signaling pathway, g onadotropin‐releasing hormone signaling pathway, and Calcium signaling pathway. We found that the distribution of differentially methylated regions peaks was mainly located in intergenic and intron regions. Altogether, our result showed that differentially methylated genes are significantly expres sed in uc.4‐overexpression cells, providing valuable data for further exploration of the role of uc.4 in heart development.
Source: Journal of Cellular Biochemistry - Category: Biochemistry Authors: Tags: RESEARCH ARTICLE Source Type: research