Phosphoinositide ‐specific phospholipase C in normal human liver and in alcohol abuse

We describe PLCs ’ expression panels in normal liver and alcohol abuse. We suggest that the regulation of PLC expression might be due to posttranscriptional events and that alcohol affects the epigenetic control of PLC expression belonging to phosphoinositide signaling. We observed alternate expression of PLCB1 an d PLCH1 genes in liver. AbstractThe phosphoinositide (PI) signal transduction pathway participates in liver metabolism. Abnormal activity or expression of PI ‐specific phospholipase C (PLC) enzymes has been described in different liver diseases. We resume the role of the PI metabolism in liver and PLC abnormalities in different liver diseases. Moreover, we present the results of PLC analyses in a normal human liver and an alcohol‐damaged liver. PLC e nzymes and the expression of the corresponding genes in liver biopsies from individuals deceased for complications of the alcoholic liver disease (ALD) at different stages compared with normal controls (deceased individuals with histologically normal livers without alcohol addiction anamnesis) were analyzed by using immunohistochemistry and molecular biology techniques. The expression panel of PLCs was described in normal and alcohol abuse liver. Our observations suggest that the regulation of PLC expression might be due to posttranscriptional events and that alcohol affects the epigenetic con trol of PLC expression belonging to PI signaling. We also describe the alternate expression of PLCB1 and PLCH1 genes in li...
Source: Journal of Cellular Biochemistry - Category: Biochemistry Authors: Tags: RESEARCH ARTICLE Source Type: research