Non-sulfated cholecystokinin-8 reduces meal size and prolongs the intermeal interval in male Sprague Dawley rats

The current study measured seven feeding responses by non-sulfated cholecystokinin-8 (NS CCK-8) in freely fed adult male Sprague Dawley rats. The peptide (0, 0.5, 1, 3, 5 and 10  nmol/kg) was given intraperitoneally (ip) prior to the onset of the dark cycle, and first meal size (MS), second meal size, intermeal interval (IMI) length, satiety ratio (SR = IMI/MS), latency to first meal, duration of first meal, number of meals and 24-hour food intake were measured. We fo und that NS CCK-8 (0.5 and 1.0 nmol/kg) reduced MS, prolonged IMI length and increased SR during the dark cycle.

Source: Neuropeptides - November 13, 2018 Category: Neuroscience Authors: Amged I. Dafalla, Thaer R. Mhalhal, Martha C. Washington, Sharonika Spann, Adalis Montero Reguero, Alexandra L. Morgan, Geishly A. Cruz Matos, Gabrielle Carson, Kenya J. Barton, Nicole A. Burke, John Heath, Ayman I. Sayegh Source Type: research