Synthesis, characterization and biological studies of rhenium, Technetium-99  m and Rhenium-188 Pentapeptides

This study shows the synthesis and characterization of KYCAR complexes containing nonradioactive rhenium, 99mTc, or 188Re. The metal complexes were also biologically evaluated to determine in vivo distribution in healthy mice. The overall goals of this project were (1) to synthesize the Tc/Re pentapeptide complexes, (2) to identify spectroscopic methods for characterization of syn versus anti rhenium peptide complexes, (3) to analyze the ex vivo stability, and (4) to assess the biological properties of the [99mTc]TcO-KYCAR and [188Re]ReO-KYCAR complexes in vivo.

Source: Nuclear Medicine and Biology - November 12, 2018 Category: Nuclear Medicine Authors: Vanessa A. Sanders, David Iskhakov, Dalya Abdel-Atti, Matthew Devany, Michelle C. Neary, Ken R. Czerwinski, Lynn C. Francesconi Source Type: research