The effect of Activin ‐A on periodontal ligament fibroblasts‐mediated osteoclast formation in healthy donors and in patients with fibrodysplasia ossificans progressiva

This study brings new insight on the role of Activin A in osteoclast formation, which may further add to understanding FOP pathophysiology; in addition to the known Activin ‐A‐mediated HO, this study shows that Activin‐A may also inhibit osteoclast formation, thereby further promoting HO formation.

Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Ton Schoenmaker, Fenne Wouters, Dimitra Micha, Tim Forouzanfar, Coen Netelenbos, E. Marelise W. Eekhoff, Nathalie Bravenboer, Teun J. de Vries Tags: ORIGINAL RESEARCH ARTICLE Source Type: research