Clonal hematopoiesis: Genes and underlying mechanisms in cardiovascular disease development

We review the genes and mechanisms of clonal hematopoiesis of indeterminate potential (CHIP) and cancer and cardiovascular disease (CVD) development. We discuss targeting mutated genes, receptors and growth factors in hematopoietic stem cells regulation and CHIP to control CVD disease. Also, we suggest novel strategies for treatment of cells and pathways involved in regulation of HSCs can be used to manage CVD treatment AbstractThe clonal hematopoiesis when occurring without hematologic abnormalities is defined as clonal hematopoiesis of indeterminate potential (CHIP). Aging causes accumulation of somatic mutations, and hematopoietic stem cells (HSCs) can develop clonal expansion of different lineages by these mutations. CHIP has a correlation with cancer and cardiovascular disease (CVD) through acquired mutations in genes.DNMT3A,TET2,ASXL1, andJAK2 genes as well as other genes are the most common somatic mutations causing CHIP and CVD in an older age. Other factors such as cholesterol level, laboratory tests and indexes also affect CVD. In addition, mutations in adenosine triphosphate –binding cassette transporters and also chronic stress in nervous system can result in HSCs proliferation and CVD. However, laboratory tests and indexes are not sensitive for CVD diagnosis. But the therapeutic interventions can be helpful to prevent CVD cases by targeting somatic mutations, chemok ine receptors, and growth factors in HSCs. Also, new drugs can control CVD by targeting of cells...

Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Habib Haybar, Saeid Shahrabi, Majid Ghanavat, Elahe Khodadi Tags: REVIEW ARTICLE Source Type: research